Cell Injury, Repair, Aging and Apoptosis A Keratinocyte Hypermotility/Growth-Arrest Response Involving Laminin 5 and p16 Activated in Wound Healing and Senescence
نویسندگان
چکیده
Easwar Natarajan,* John D. Omobono II,* Zongyou Guo,* Susan Hopkinson, Alexander J.F. Lazar, Thomas Brenn, Jonathan C. Jones, and James G. Rheinwald* From the Departments of Dermatology * and Pathology, Brigham and Women’s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts; and the Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois
منابع مشابه
Co-expression of p16INK4A and laminin 5 by keratinocytes: a wound-healing response coupling hypermotility with growth arrest that goes awry during epithelial neoplastic progression.
The replicative lifespan of human keratinocytes in culture is restricted by a telomere-unrelated induction of p16INK4A (p16) and p14ARF. We have found that, in vivo, p16 is expressed by epidermal and oral keratinocytes at the migrating fronts of healing wounds and at the stromal interface of severely dysplastic and early invasive lesions and that such cells also invariably display increased exp...
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